Table 7

Pharmacokinetic data for acute administration of GT-2331

GT-2331CmaxT1/2AUCallAUCVd7-aCl7-bMRT7-c
mg/kg ng/ml h ng·h/ml ng·h/ml l/kg ml/min/kg h
1.0 (n = 4)8104.8243725054.928.52.8
  • 7-a V d = MRT × Cl.

  • 7-b Cl = Dose/AUCall (the dose was calculated by multiplying the average weight for the group and the dose in mg/kg).

  • 7-c MRT = AUMCall/AUCall. The AUMCall was 8282 ng·h/ml.