In vitro HA H3 binding affinities and ex vivo binding profile for selected H3 receptor antagonists
| Compound | HA H3,Ki Mean ± S.E. | ED50, i.p., Mean ± S.E. |
|---|---|---|
| nM | mg/kg | |
| GT-2208 | 3.6 ± 1.0 | 1.47 ± 0.32 |
| GT-2212 | 8.8 ± 0.1 | 20.9 ± 2.9 |
| GT-2331 | 0.12 ± 0.04 | 0.08 ± 0.03 |