Table 6
In vitro HA H
3
binding affinities and ex vivo binding profile for selected H
3
receptor antagonists
Compound
HA H
3
,
K
i
Mean ± S.E.
ED
50
, i.p., Mean ± S.E.
nM
mg/kg
GT-2208
3.6 ± 1.0
1.47 ± 0.32
GT-2212
8.8 ± 0.1
20.9 ± 2.9
GT-2331
0.12 ± 0.04
0.08 ± 0.03