Severity of cardiotoxicity in male rabbits after multiple treatments with PL-DOX or nonliposomal doxorubicin
| Test Material (Cumulative Dose) | Weeks Postdose | N4-a | Cardiotoxicity Score, Median (Range) |
|---|---|---|---|
| Doxorubicin (14 mg/kg) | 1 | 1 | 1 |
| 5 | 1 | 1 | |
| 13 | 3 | 1 (1–4) | |
| U4-b | 5 | 6 (3–11) | |
| PL-DOX (14 mg/kg) | 1 | ||
| 5 | |||
| 13 | 1 | 4 | |
| U4-b | 2 | 2.5 (1–5) | |
| PL-DOX (21 mg/kg) | 13 | ||
| U4-b | 1 | 2 |