Table 3

Incidence of heart lesions in male rabbits treated with PL-DOX or nonliposomal doxorubicin

Necropsy^3-a	Saline	PL-DOX 1.0 mg/kg	DOX 1.0 mg/kg
14 mg/kg Cumulative Dose
1-Week	0 /5	0 /4	1 /2
5-Week	0 /5	0 /5	1 /3
13-Week	0 /5	1 /4	3 /5
Early Deaths		2 /2^3-b	5 /5^3-c
Total Affected (%)	0 /15 (0)	3 /15 (20)	10 /15 (67)
21 mg/kg Cumulative Dose
13-Week	0 /5	0 /3
Early Deaths	0 /5	1 /7^3-d
Total Affected (%)	0 /10 (0)	1 /10 (10)

↵3-a Weeks after last dose.
↵3-b Cumulative delivered dosage of 14 mg/kg. Deaths occurred on days 87 and 143.
↵3-c Cumulative delivered dosage of 12 to 14 mg/kg. Deaths occurred between days 82 and 98.
↵3-d Cumulative delivered dosage of 21 mg/kg. Death occurred on day 216.