Epidural pharmacokinetic parameters (mean ± S.D.) of BUP and LID after separate epidural administration of equimolar dose (6.9 μM: 2 mg of BUP and 1.62 mg of LID) in rabbits
| BUP | LID | |
|---|---|---|
| Cmax(μg/ml) | 705 ± 289 | 980 ± 280 |
| (mM) | 2.45 ± 1.00 | 4.15 ± 1.18 |
| CLE(ml/min) | 0.140 ± 0.011 | 0.084 ± 0.0321-150 |
| CLI(ml/min) | 0.142 ± 0.074 | 0.035 ± 0.006 |
| V 1 (ml) | 1.51 ± 0.07 | 1.22 ± 0.101-160 |
| V SS (ml) | 7.13 ± 6.78 | 4.09 ± 0.55 |
| K 12 (min−1) | 0.093 ± 0.046 | 0.029 ± 0.003 |
| K 21(min−1) | 0.041 ± 0.018 | 0.012 ± 0.0011-150 |
| K 10 (min−1) | 0.093 ± 0.010 | 0.068 ± 0.020 |
| T 1/2α(min) | 3.4 ± 0.6 | 7.1 ± 1.41-160 |
| T 1/2β (min) | 52.7 ± 46.1 | 85.0 ± 6.9 |