Renal functional parameters of the isolated perfused rat kidney during perfusion with 10 μM LY without or with pretreatment with probenecid or α-ketoglutarate
| Parameter | Control (untreated) | Control LY | Probenecid | α-Ketoglutarate |
|---|---|---|---|---|
| GFR (μl/min) | 277 ± 35 | 316 ± 78 | 318 ± 116 | 335 ± 28 |
| Urinary flow (μl/min) | 18 ± 3 | 15 ± 3 | 20 ± 4 | 22 ± 2 |
| Urinary pH | 5.8 ± 0.3 | 6.1 ± 0.2 | 6.4 ± 0.3 | 6.2 ± 0.2 |
| FENa (%) | 2.9 ± 0.6 | 1.9 ± 0.5 | 2.4 ± 0.7 | 2.7 ± 0.3 |
| FEglucose (%) | 7.3 ± 2.1 | 5.7 ± 2.5 | 9.9 ± 2.8 | 6.0 ± 1.9 |
| FRwater (%) | 94 ± 1 | 94.5 ± 0.6 | 93 ± 1 | 93.6 ± 0.3 |
| RPP (mm Hg) | 89 ± 8 | 87.1 ± 0.4 | 92 ± 3 | 90 ± 1 |
Values are presented as mean ± S.D. (n = 4; for untreated controls, n = 12). FE, fractional excretion; FR, fractional reabsorption; RPP, renal perfusion pressure.