Equieffective total doses and interaction index for % MPE = 50
| Combination | Set 1 | Set 2 | Set 3 |
|---|---|---|---|
| Proportion4-a | p = .605 | p = .338 | p = .821 |
| Z add | 4.82 | 4.30 | 5.33 |
| Z mix | 1.43 | 0.223 | 0.414 |
| α | 0.297 | 0.052 | 0.077 |
↵4-a Proportion (p) of the total mass that is morphine sulfate. Proportions are based on estimatedD50 values of morphine (M) and clonidine (C) constituents: Set 1, 0.5 (M), 0.5 (C); Set 2, 0.25 (M), 0.75 (C); Set 3, 0.75 (M), 0.25 (C).