Biliary metabolites of [14C]arteflene in male rats
| Time | % of Radiolabeled Dose Present as Metabolite | ||
|---|---|---|---|
| 8-Hydroxyarteflene glucuronide | Cisenone | Trans enone | |
| h | |||
| 0–1 | 8.6 ± 2.1 | 3.2 ± 1.0 | 0.9 ± 0.3 |
| 1–2 | 4.2 ± 1.4 | 2.8 ± 0.8 | 1.4 ± 0.6 |
| 2–3 | 1.4 ± 0.4 | 4.1 ± 1.6 | 1.1 ± 0.3 |
| 0–3 | 14.2 ± 3.9 | 10.1 ± 3.4 | 3.4 ± 1.2 |
[14C]Arteflene (35 μmol/kg) was administered i.v. to anesthetized and cannulated male rats.
Data are mean ± S.D. (n = 7); two rats excreting only trace amounts of 8-hydroxyarteflene glucuronide are excluded.