Table 3

Renal function, blood pressure, and adverse events at enalapril 10 and 40 mg daily as well as at lowest and highest enalaprilat trough level

EnalaprilEnalaprilat Level
10 mg40 mgLowestHighest
Serum creatinine100  ± 14 μmol/liter101  ± 15 μmol/liter102  ± 20 μmol/liter107  ± 26 μmol/liter
Serum potassium3.7  ± 0.3 mmol/liter3.8  ± 0.3 mmol/liter3-a 3.7  ± 0.3 mmol/liter3.8  ± 0.4 mmol/liter3-d
Hypokalemia28%7%3-a 29%16%3-c
Systolic BP supine116  ± 15 mm Hg112  ± 14 mm Hg3-b 117  ± 13 mm Hg112  ± 14 mm Hg3-d
Diastolic BP supine67  ± 10 mm Hg65  ± 9 mm Hg69  ± 11 mm Hg66  ± 9 mm Hg3-e
Systolic BP standing110  ± 14 mm Hg108  ± 14 mm Hg110  ± 13 mm Hg108  ± 14 mm Hg
Diastolic BP standing66  ± 10 mm Hg64  ± 9 mm Hg65  ± 10 mm Hg64  ± 8 mm Hg
Orthostasis13%30%3-b 15%27%3-c
Cough score3-e 1.2  ± 1.51.4  ± 1.91.4  ± 1.71.7  ± 2.13-c
  • BP, blood pressure.

  • 3-a Significance, p < .05 between 10 and 40 mg enalapril.

  • 3-b Significance, p < .01 between 10 and 40 mg enalapril.

  • 3-c Significance, p < .05 between lowest and highest enalaprilat trough level.

  • 3-d Significance, p < .01 between lowest and highest enalaprilat trough level.

  • 3-e Cough score on a scale of 0 to 8.