Calculated conductance slopes for Ca2+-activated leakage currents induced by δ-HCH
| Ionic Condition (cis/trans) | Current Modifier | Current Slope |
|---|---|---|
| pA/mV | ||
| 500 mM CsCl | Control | 0.01 ± <0.01 |
| (Fig. 2A) | 50 μM γ-HCH + 50 μM Ca2+(cis) | 0.02 ± 0.01 |
| (Fig. 3A) | 50 μM δ-HCH + 50 μM Ca2+ (cis) | 1.28 ± 0.05 |
| 100 mM CsCl | Control | 0.01 ± <0.01 |
| (Fig. 6A) | 50 μM δ-HCH (cis) | 0.09 ± <0.01 |
| +50 μM Ca2+(cis) | 1.33 ± 0.08 | |
| +350 μM Ca2+(cis) | 4.70 ± 0.22 | |
| +700 μM Ca2+(cis) | 6.15 ± 0.10 | |
| +1.15 mM Ca2+(cis) | 7.49 ± 0.09 | |
| +1.65 mM Ca2+(cis) | 7.89 ± 0.11 | |
| 1 mM CaCl2 | Control | 0.07 ± 0.01 |
| (Fig. 5A) | 50 μM δ-HCH (cis) | 0.35 ± 0.01 |
| 100 mM CsMeSo3 | Control | 0.04 ± <0.01 |
| (Fig. 5B) | 50 μM δ-HCH (cis) | 0.22 ± 0.01 |
| +50 μM Ca2+ (cis) | 1.37 ± 0.04 | |
| 100 mM KCl | Control | 0.27 ± <0.01 |
| (Fig. 2B) | 50 μM δ-HCH (cis) | 0.49 ± 0.01 |
| +50 μM Ca2+(cis) | 4.25 ± 0.03 | |
| Control | 0.09 ± <0.01 | |
| (Fig. 3B) | 50 μM γ-HCH (cis) | 0.01 ± <0.01 |
| +50 μM Ca2+ (cis) | 0.01 ± <0.01 | |
| 100 mM NaCl | Control | 0.14 ± <0.01 |
| (Fig.2C) | 50 μM δ-HCH (cis) | 0.18 ± 0.01 |
| +50 μM Ca2+ (cis) | 0.66 ± 0.01 | |
| (Fig. 3C) | Control | 0.01 ± <0.01 |
| 50 μM γ-HCH (cis) | 0.01 ± <0.01 | |
| +50 μM Ca2+(cis) | 0.01 ± <0.01 |