Treatment Group (dose) | Kidney Swelling of proximal tubules and edema | Liver Swelling of hepatic sinusoids and damage of lobular architecture | Liver Compression of alveoli and increased thickness of epithelium |
---|---|---|---|
NAMI-A (35 mg/kg) | +++ | ++ | + |
Cisplatin (2 mg/kg) | ++++ | ++++ | +++ |
Kidneys, livers, and lung of three different mice, implanted with MCa mammary carcinoma on day 0 and dosed i.p. with NAMI-A or cisplatin daily on days 14–19, were removed from animals 24 h after last dose, fixed with formalin, and examined with light microscopy. For each animal, three different glasses, each mounted with four different slices, were read completely in a single blind procedure.
+, Focal; ++, moderate; +++, diffuse; ++++, marked and generalized.