Table 3

Effects of M₃ receptor inactivation and AF-DX 116 (1 μM) on the responses predicted by model II

Component	Case	M₃ Receptor Inactivation	Increase in EC₅₀ Value^3-a	Decrease in Maximal Response^3-a	Dextral Shift Produced by AF-DX 116 (1 μM)^3-b
		%	fold	%
A	N.A.	0	N.A.	N.A.	2.3
		90	11.2	0	2.3
		99	138.9	50.8	2.3
		99.8	235.0	96.2	2.3
B	1	0	N.A.	N.A.	19.6
		90	1.0	0	19.6
		99	4.0	0	6.1
		99.8	23.0	21	2.3
	2	0	N.A.	N.A.	6.3
		90	10.2	0	2.3
		99	125.5	50.9	2.3
		99.8	185.8	96.3	2.3
	3	0	N.A.	N.A.	12.6
		90	7.0	0	3.3
		99	125.5	50.9	2.3
		99.8	185.8	96.3	2.3
A + B	1	0	N.A.	N.A.	2.3
		90	6.5	0	3.7
		99	53.9	24.3	3.2
		99.8	85.3	72.8	2.3
	2	0	N.A.	N.A.	2.3
		90	10.5	0	2.6
		99	164.8	37.6	2.3
		99.8	291.4	95.1	2.3
	3	0	N.A.	N.A.	2.3
		90	10.5	0	2.6
		99	164.8	37.6	2.3
		99.8	291.4	95.1	2.3

The effects on components A and B and their combination are shown.

↵3-a This parameter was calculated by comparison with the control (0% M₃ inactivation) curve.
↵3-b This parameter was calculated by comparison with the curve of equal receptor inactivation.