Drug | Ki | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
D1 | hD2 | hD3 | hD4 | h5-HT1A | 5-HT2A | h5-HT2B | 5-HT2C | 5-HT6 | 5-HT7 | α1 | α2 | hM1 | |
Clozapine (n = 4) | 0.56 | 0.73 | 0.70 | 0.07 | −0.41 | 0.35 | −0.36 | 0.10 | 0.03 | −0.45 | −0.35 | −0.48 | −0.06 |
S-16924 (n = 6) | 0.72* | 0.76* | 0.63 | 0.63 | 0.32 | 0.83* | 0.34 | 0.65 | 0.50 | 0.35 | 0.27 | 0.16 | −0.30 |
Values are Pearson Product correlation coefficients. h = human. n = number of multireceptorial antipsychotics for which precise ED50s for generalization were obtained: clozapine, S-16924, quetiapine, olanzapine, and, for the S-16924 correlation, ORG-5222 and ziprasidone. In addition, in vivo doses were expressed as μmol/kg and affinities as log Ki. Asterisks indicate significant correlation of the potency to generalize to clozapine or S-16924 (* P < .05) with affinity at an individual receptor type.