Table 1

Interaction between CX516 and antipsychotic drugs: percentage of methamphetamine-induced activity after indicated treatment

AntipsychoticActivityAntipsychotic AloneCX516 AloneCX516 plus Antipsychotic
HaloperidolRearing8174 281-d
 (0.06 mg/kg)1-a Crossing105104 47b,c
Haloperidol Rearing3157 161-c
 (0.12 mg/kg)Crossing3457 241-c
Clozapine Rearing10566 10e,f
 (1 mg/kg)Crossing106132 651-g
RisperidoneRearing5075−6b,c
 (0.1 mg/kg)Crossing5396 421-g
  • 1-a The dose of CX516 was 10 mg/kg in all experiments except 30 mg/kg in this case.

  • 1-b P < .05 versus methamphetamine plus antipsychotic by Dunn’s test after Kruskal-Wallis test (one-way ANOVA).

  • 1-c P < .05 versus methamphetamine plus CX516 (Dunn’s test after Kruskal-Wallis test).

  • 1-d P < .01 versus methamphetamine plus antipsychotic (Dunn’s test after Kruskal-Wallis test).

  • 1-e P < .01 versus methamphetamine plus CX516 (Dunn’s test after Kruskal-Wallis test).

  • 1-f P < .001 versus methamphetamine plus antipsychotic (Dunn’s test after Kruskal-Wallis test).

  • 1-g Not significant by Dunn’s test after Kruskal-Wallis test.