Characteristics of vehicle-treated sham-operated rats and vehicle-treated rats with myocardial infarction
| Sham-Operated Rats | Vehicle-Treated Infarct Rats | P | |
|---|---|---|---|
| Blood pressure (mmHg, day 2–27) | 118.0 ± 0.9 | 112 ± 1.3 | 0.0003 |
| Body weight (g, day 27) | 337 ± 6 | 309 ± 7 | 0.01 |
| Heart weight/body weight ratio (mg/g) | 2.89 ± 0.05 | 3.20 ± 0.09 | 0.008 |
| Lung weight/body weight ratio (mg/g) | 4.5 ± 0.2 | 4.7 ± 0.5 | N.S. |
| Plasma renin (pmol Ang I/ml/h) | 4.2 ± 0.5 | 4.3 ± 0.7 | N.S. |
| Plasma angiotensinogen (pmol/ml) | 367 ± 26 | 317 ± 13 | N.S. |
| Plasma ACE (U/liter) | 281 ± 11 | 300 ± 20 | N.S. |
| Urine volume (μl/min) | 23.5 ± 0.9 | 25.9 ± 0.7 | N.S. |
| Urine cGMP (pmol/min) | 18.4 ± 1.5 | 24.2 ± 2.5 | 0.04 |
| Urine sodium (μmol/min) | 0.64 ± 0.07 | 0.73 ± 0.07 | N.S. |
| Urine potassium (μmol/min) | 1.2 ± 0.1 | 1.3 ± 0.2 | N.S. |
| Urine BK-(1–7) (fmol/min) | 0.38 ± 0.03 | 0.64 ± 0.09 | 0.013 |
| Urine BK-(1–8) (fmol/min) | 0.039 ± 0.006 | 0.136 ± 0.048 | 0.045 |
| Urine BK-(1–9) (fmol/min) | 0.16 ± 0.03 | 0.11 ± 0.02 | N.S. |
| Urine BK-(1–7)/BK-(1–9) ratio (mol/mol) | 14 ± 5 | 12 ± 5 | N.S. |
| Plasma Ang II (fmol/ml) | 21 ± 2 | 24 ± 3 | N.S. |
| Plasma Ang I (fmol/ml) | 12 ± 1 | 7 ± 1 | 0.01 |
| Plasma Ang II/Ang I ratio (mol/mol) | 1.9 ± 0.2 | 5.4 ± 1.4 | 0.02 |
Each value represents mean ± S.E.M., n = 9 to 15 per group. Blood pressure data are shown as mean of data for days 2, 7, 14, 21, and 27 after surgery, analyzed by repeated measures ANOVA.