Drug | Levodopa Alone | 1 nM | 10 nM | 100 nM | 1 μM | 10 μM | 100 μM | CM | PC |
---|---|---|---|---|---|---|---|---|---|
7-OH-DPAT | 53 ± 15.6 | 54.5 ± 16.3 | 60.5 ± 9.2 | 56.5 ± 4.9 | 52 ± 5.7 | 46.5 ± 0.7 | 50 ± 2.8 | 294 ± 18.4 | 84.5 ± 9.2 |
U95666 | 82.5 ± 6.4 | 67 ± 11.3 | 79 ± 12.7 | 77 ± 18.4 | 70 ± 4.2 | 70 ± 4.2 | 23.5 ± 7.8 | 305.5 ± 10.6 | 96.5 ± 10.6 |
U99194 | 66.5 ± 14.8 | 68.5 ± 17.7 | 69 ± 8.5 | 79.5 ± 13.4 | 74 ± 4.2 | 73.5 ± 9.2 | 67 ± 2.8 | 302 ± 99.5 | 99.5 ± 7.8 |
Domperidone | 58 ± 15.6 | 58.5 ± 23.3 | 46.5 ± 12.0 | 57 ± 8.5 | 64.5 ± 29.0 | 65.5 ± 13.4 | 51.5 ± 24.7 | 290.5 ± 9.2 | 110.5 ± 24.7 |
U101033E | 43 ± 4.2 | Not done | 47 ± 5.6 | 50 ± 11.3 | 46.5 ± 11.3 | 94.5 ± 13.43-150 | 226 ± 2.83-150 | 200.5 ± 7.8 | 52 ± 9.8 |
All drug concentrations are in addition to 10 μM levodopa.
↵3-150 p < .05 versus levodopa.