Parameter | |
---|---|
V1(l/kg) | 0.85 [0.50] {0.42} |
Vss(l/kg) | 34.9 [32.5] {4.5} |
α T 1/2(min) | 0.80 [0.55] {0.24} |
β T 1/2(min) | 13.6 [12.3] {2.4} |
γ T 1/2(min) | 455 [479] {59} |
α (min−1) | 1.12 [1.27] {0.22} |
β (min−1) | 0.058 [0.057] {0.011} |
γ (min−1) | 0.0016 [0.0015] {0.0002} |
k21 (min−1) | 0.083 [0.10] {0.021} |
k31 (min−1) | 0.033 [0.007] {0.027} |
Clearance (l/kg/min) | 0.066 [0.071] {0.009} |
MRT (min) | 564 [670] {85} |
S.E.M. indicates standard error of the mean; V1, initial volume of distribution; Vss; volume of distribution at steady state; T1/2, half-life of a given exponential; α, β, and γ represent the three constants in the triexponential function; k21 and k31 express the mass transfer of ET-1 from the two peripheral compartments (compartments two and three, respectively) to the central compartment; Clearance represents total clearance from plasma; MRT, mean residence time.