Compound | N. naja Venom %I (10 μM) | Pancreas %I (10 μM) IC50 | Human Synovial %I (10 μM) IC50 | Bee Venom %I (10 μM) IC50 |
---|---|---|---|---|
Petrosaspongiolide M | 11.5 ± 3.0 | 12.3 ± 6.0 | 68.6 ± 2.7** 4.3 | 1.0 ± 1.8** 0.6 |
Manoalide | 17.0 ± 1.7* | 32.3 ± 2.7** N.D. | 93.2 ± 0.2** 3.9 | 62.5 ± 3.8** 7.5 |
Results are mean ± S.E.M. (n = 6). * P < .05, ** P < .01 compared with the enzyme control group.
% I, percentage of inhibition. IC50 values were determined for compounds that reach unless 50% inhibition at 10 μM.
N.D., not determined.