Dose | Heart Rate | P-R | QRS | Q-T | |
---|---|---|---|---|---|
μmol/kg/min | bpm | ms | ms | ms | |
Vehicle | 403 ± 9 | 59 ± 1 | 29 ± 1 | 37 ± 1 | |
RSD1000 | 1 | 376 ± 11 | 61 ± 1 | 31 ± 1 | 37 ± 1 |
2 | 362 ± 16 | 63 ± 2 | 29 ± 1 | 40 ± 1 | |
4 | 349 ± 182-a | 64 ± 32-a | 32 ± 1 | 45 ± 12-a | |
8 | 305 ± 122-a | 70 ± 32-a | 31 ± 1 | 52 ± 12-a | |
Sham occlusion | 8 | ||||
5 min postinfusion | 297 ± 142-a | 69 ± 42-a | 31 ± 2 | 55 ± 32-a | |
20 min postinfusion | 281 ± 82-a | 71 ± 42-a | 31 ± 3 | 56 ± 32-a |
Heart rate and ECG variables were recorded 5 min after beginning infusion of RSD100 (in μmole/kg/min) in ischemic arrhythmia study. Values are mean ± S.E.M., n = 7. In sham occlusion study, variables were measured 5 and 20 min after infusion of 8.0 μmol/kg/min RSD1000.
↵2-a P < .05 versus predrug for each dose (t test).