TP (mV) | Control | Hypo | Amio | Hypo + Amio | DMSO | |
---|---|---|---|---|---|---|
I Ks Step (pA/pF) | +50 | 2.44 ± 0.37 | 0.86 ± 0.20b | 1.38 ± 0.26a,d | 0.95 ± 0.18b | 2.81 ± 0.51 |
I Ks Tail (pA/pF) | +50 | 0.72 ± 0.13 | 0.15 ± 0.02c | 0.38 ± 0.06a,d | 0.20 ± 0.04b | 0.79 ± 0.18 |
I Kr Step (pA/pF) | 0 | 0.28 ± 0.04 | 0.26 ± 0.02 | 0.12 ± 0.02c,e | 0.10 ± 0.03c,e | 0.31 ± 0.04 |
I Kr Tail (pA/pF) | 0 | 0.28 ± 0.07 | 0.24 ± 0.02 | 0.08 ± 0.01a,d | 0.09 ± 0.03a,d | 0.31 ± 0.08 |
Number of Cells | 8 | 9 | 8 | 7 | 5 |
TP, test potential; tail currents were recorded upon repolarization to −40 mV from TP indicated; Hypo, hypothyroid; Amio, amiodarone-treated; Hypo + Amio, amiodarone-treated hypothyroid animals; DMSO, dimethylsulfoxide-treated animals.
3-a P < .05, b P < .01, c P < .001 versus control;d P < .05, e P < .001 for Amio or Hypo + Amio versus Hypo.