Values of apparent tissue-to-plasma concentration ratio (Kp, app) of total radioactive carnitine, unchangedl-[3H]carnitine, and [acetyl-3H]carnitine at 4 h after an injection of l-[3H]carnitine (250 ng/kg i.v.) in mice
| Tissue | Normal Mice | JVS Mice | ||||
|---|---|---|---|---|---|---|
| Total Radioactive Carnitine | Unchanged l-[3H]Carnitine | [acetyl-3H]Carnitine | Total Radioactive Carnitine | Unchanged l-[3H]Carnitine | [acetyl-3H]Carnitine | |
| Brain | 0.38 ± 0.05 | 1.14 ± 0.15 | 0.211 | 0.47 ± 0.17 | 0.8 ± 0.29 | 0.269 |
| Lung | 6.92 ± 1.25 | 20.7 ± 3.7 | 1.33 | 5.18 ± 1.59 | 9.5 ± 2.91a | 0.935 |
| Heart | 7.89 ± 1.58 | 24.4 ± 4.9 | 1.06 | 0.67 ± 0.14b | 1.22 ± 0.26b | 0.164 |
| Liver | 8.71 ± 0.60 | 29.5 ± 2.0 | 0.068 | 3.96 ± 0.22c | 8.34 ± 0.47c | N.D. |
| Kidney | 9.82 ± 2.10 | 31.6 ± 6.74 | 0.810 | 5.60 ± 0.74 | 10.8 ± 1.43a | 0.985 |
| Gut | 4.98 ± 0.19 | 15.8 ± 0.6 | 0.560 | 2.72 ± 1.12 | 5.37 ± 2.21b | 0.293 |
| Spleen | 10.4 ± 3.5 | 31.6 ± 6.7 | 1.81 | 2.69 ± 1.86 | 5.07 ± 3.05a | 0.365 |
| Muscle | 1.05 ± 0.20 | 2.16 ± 0.41 | 0.610 | 0.45 ± 0.08 | 0.54 ± 0.10b | 0.280 |
Each value represents mean ± S.E.M. of four mice.
N.D., not determined.
Significantly different from normal mice ata p < .05, b p < .01, and c p < .001.