Table 4

PS products calculated from apparent exchangeable fractions obtained by i.c.a. injection method or perfusion method and in vitro unbound fraction

CompoundPS products (×10−3 ml/s/g)
i.c.a. Injection4-aPerfusion4-aUltrafiltration In Vitro4-b
Diazepam21.34-c NDCNC
Caffeine11.2  (3.00)10.4  (4.30)13.3  (5.78)
S-312-d7.50  (0.900)12.8  (1.67)CNC
Glucose1.53  (0.300)1.53  (0.300)1.53  (0.300)
(+)-S-145 Na1.37  (0.595)2.32  (1.03)3.20  (1.45)
S-85101.21  (0.309)ND2.05  (0.540)

  • Mean (S.D.) (n = 3–6). ND, not determined; CNC, could not be calculated.

  • ↵4-a Calculated using apparent exchangeable fraction.

  • ↵4-b Calculated using unbound fraction in vitro.

  • ↵4-c PS product of diazepam was calculated fromk3t of i.c.a. injection method (see detail for method).