Table 3

Comparison of unbound fraction measured by ultrafiltration and apparent exchangeable fraction measured by fitting the data of i.c.a. injection method of diazepam

Concentration of BSA (mM)
00.170.330.50.670.83
Unbound fraction (%)10027.516.912.29.58.1
Apparent exchangeable fraction (%)10099.997.796.595.494.4
Ratio of unbound to apparent exchangeable fraction13.65.87.91011.7