Concentrations of pyrrolopyrimidines in mouse tissues and plasma after single intravenous dose
| PNU-87663 | PNU-89843 | |||
|---|---|---|---|---|
| 5 min | 60 min | 5 min | 60 min | |
| Brain (nmol/g) | 17.7 ± 1.1 | 6.7 ± 3.6 | 12.1 ± 1.3 | 1.6 ± 0.2 |
| Lung (nmol/g) | 19.4 ± 2.1 | 4.0 ± 0.5 | 4.0 ± 0.1 | 0.8 ± 0.7 |
| Heart (nmol/g) | 31.2 ± 5.2 | 2.7 ± 0.8 | 6.3 ± 1.3 | 1.2 ± 0.1 |
| Plasma (nmol/ml) | 8.0 ± 0.3 | 1.1 ± 0.5 | 8.0 ± 0.6 | 1.3 ± 0.1 |
Female mice were injected via tail vein with 23 μmol/kg (∼10 mg/kg) compound in propylene glycol, and samples were collected at two time points after transcardiac perfusion with normal saline.