Table 1

Chemical structures, calculated log Poct, transepithelial permeability coefficient, cell partitioning, and mass balance of pyrrolopyrimidine analogs assayed using MDCK cell monolayers 

Table 1
graphic
CompoundR1 R2 CLOGP1-a Pe1-b Cell1-c Mass Balance
% %

  • ↵1-a Calculated log Poct/water.

  • ↵1-b Apparent permeability coefficient × 10−6(cm/s).

  • ↵1-c Percent of donor mass equilibrating with the cell monolayer.

  • 1-150  Some metabolism detected.