Potencies of spiperone and SCH 39166 to decrease spontaneous locomotor activity (alone) and to block the locomotor stimulant effects of sydnocarb (10 mg/kg s.c.) or methamphetamine (0.3 mg/kg s.c.)
| Treatment | ED50 (95% CL) | ED50Antagonist/ ED50 Drug Combination |
|---|---|---|
| Horizontal activity | ||
| SCH 39166 alone | 0.07 (0.05–0.1) | |
| Spiperone alone | 0.07 (0.05–0.1) | |
| SCH + methamphetamine | 0.001 (0.0004–0.003) | 70.0 |
| Spiperone + methamphetamine | 0.02 (0.015–0.028) | 3.5 |
| SCH + sydnocarb | 0.003 (0.001–0.007) | 23.3 |
| Spiperone + sydnocarb | 0.007 (0.004–0.02) | 10.0 |
| Vertical activity | ||
| SCH 39166 alone | 0.09 (0.04–0.17) | |
| Spiperone alone | 0.07 (0.03–0.18) | |
| SCH + methamphetamine | 0.002 (0.0004–0.008) | 45.0 |
| Spiperone + methamphetamine | 0.01 (0.004–0.03) | 7.0 |
| SCH + sydnocarb | 0.002 (0.0006–0.01) | 45.0 |
| Spiperone + sydnocarb | 0.0007 (0.00002–0.02) | 100.0 |