Table 2

Inhibition of rat and human COX-1 and COX-2 by (R,S)-, (S)-, and (R)-ketorolac

Compound	Rat COX ID₅₀^2-a		Human COX ID₅₀^2-a
Compound	rCOX-1	rCOX-2	rCOX-1/rCOX-2	hCOX-1	hCOX-2	hCOX-1/hCOX-2
		μM			μM
(R,S)-ketorolac	0.27 ± 0.06	2.06 ± 0.95	0.13	1.23 ± 0.16	3.50 ± 0.63	0.35
(S)-ketorolac	0.10 ± 0.08	0.79 ± 0.60	0.13	0.46 ± 0.08	1.46 ± 0.43	0.32
(R)-ketorolac	>100^2-b	>100^2-b		>100^2-b	>100^2-b
DS	0.20 ± 0.11	0.60 ± 0.18	0.33	0.90 ± 1.22	1.50 ± 0.80	0.60
INDO	0.22 ± 0.14	6.90 ± 2.00	0.03	0.66 ± 0.56	14.56 ± 9.30	0.04
Celecoxib	57.2 ± 24.9	0.04 ± 0.01	1431

↵2-a Values are mean ± S.E. from at least three separate determinations.
↵2-b Due to the weakness of binding, an ID₅₀ value could not be determined.
2-c Values previously reported (Ramesha, 1996).