Agonist | PNU-151774E | n | Control | PNU-151774E (without incubation) | PNU-151774E (with 5-min incubation) | Washout |
---|---|---|---|---|---|---|
μM | ||||||
55 mM KCl | 100 | 4 | 100 ± 36 | 70 ± 64-a | 48 ± 34-a | 65 ± 44-a |
10 μM veratridine | 100 | 4 | 100 ± 7 | 24 ± 64-a | 3 ± 14-a | 66 ± 24-a |
30 | 4 | 100 ± 3 | 79 ± 34-a | 39 ± 54-a | 107 ± 6 | |
10 | 4 | 100 ± 2 | 103 ± 2 | 106 ± 2 | 129 ± 34-a |
Results represent the area under the curve (nmoles of calcium) and are expressed as percentage of predrug control response;n, number of coverslips studied. See text for details.
↵4-a Significantly different from control, P < .01.