Effects of L-754,142 on LV EES/EA, SW, and work efficiency in dogs before and after CHF
| Before CHF | After CHF | |||
|---|---|---|---|---|
| Control | ET-1 blocker | Control | ET-1 blocker | |
| EES/EA | 0.78 ± 0.03 | 0.80 ± 0.07 | 0.36 ± 0.03 | 0.59 ± 0.075-150 |
| SW (mm Hg ml) | 1566 ± 153 | 1544 ± 111 | 985 ± 182 | 1074 ± 1995-150 |
| SW/PVA | 0.55 ± 0.02 | 0.57 ± 0.03 | 0.37 ± 0.03 | 0.45 ± 0.035-150 |
EA, arterial elastance; SW, stroke work; PVA, LV pressure-volume area. Values are mean ± S.E. (n = 7).
↵5-150 P < .05 versus control after CHF.