Effects of ET-1 blocker on the PES-VES, dP/dtmax-VED, and SW-VED relations before and after CHF
| PES-VESRelation | dP/dtmax-VEDRelation | SW-VED Relation | |||||||
|---|---|---|---|---|---|---|---|---|---|
| EES | V0,ES | V100,ES | dE/dtmax | V0,dP/dt | V1000,dP/dt | MSW | V0,SW | V1000,SW | |
| Before CHF | |||||||||
| Control | 5.3 ± 0.7 | 9.0 ± 2.6 | 29.4 ± 3.1 | 82.0 ± 12.8 | 4.8 ± 2.1 | 18.8 ± 1.9 | 78.1 ± 4.4 | 24.8 ± 2.8 | 37.8 ± 2.5 |
| ET-1 blocker | 5.3 ± 0.8 | 8.8 ± 3.0 | 29.6 ± 3.2 | 82.3 ± 11.4 | 5.3 ± 1.7 | 18.7 ± 2.1 | 81.2 ± 7.5 | 24.3 ± 2.4 | 37.2 ± 2.9 |
| After CHF | |||||||||
| Control | 3.4 ± 0.43-150 | 15.7 ± 0.63-150 | 47.3 ± 3.53-150 | 42.4 ± 7.83-150 | 13.1 ± 2.23-150 | 42.0 ± 6.33-150 | 58.1 ± 3.33-150 | 37.7 ± 3.73-150 | 55.2 ± 3.63-150 |
| ET-1 blocker | 4.8 ± 0.83-160 | 17.4 ± 0.93-160 | 41.2 ± 3.93-160 | 50.0 ± 7.83-160 | 15.5 ± 2.03-160 | 38.8 ± 5.03-160 | 72.4 ± 5.23-160 | 38.2 ± 3.4 | 51.8 ± 4.13-160 |
V0,ES, intercept with volume axis; V100,ES, volume associated with a PES of 100 mm Hg; dE/dtmax, slope of dP/dtmax-VED relation; V0,dP/dt, intercept with volume axis; V1000,dP/dt, volume associated with a dP/dt of 1000 mm Hg/s; V0,SW, intercept with volume axis, and V1000,SW, volume associated with SW of 1000 mm Hg ml. Values are mean ± S.E. (n = 7).
↵3-150 P < 0.05, control value after CHF versus corresponding normal control value before CHF.
↵3-160 P < 0.05, ET-1 blocker versus corresponding control value.