Effects of ET-1 blocker on steady-state hemodynamics and ET-1 plasma concentration before and after CHF
| Before CHF | After CHF | |||
|---|---|---|---|---|
| Control | ET-1 blocker | Control | ET-1 blocker | |
| Heart rate (beats/min) | 111 ± 17 | 114 ± 17 | 118 ± 162-150 | 119 ± 19 |
| Peak +dP/dt (mm Hg/s) | 2604 ± 295 | 2549 ± 282 | 1550 ± 4332-150 | 1757 ± 2892-160 |
| Peak −dP/dt (mm Hg/s) | −2295 ± 300 | −2261 ± 280 | −1631 ± 3252-150 | −1780 ± 2282-160 |
| LVPED(mm Hg) | 10.9 ± 2.9 | 10.7 ± 3.3 | 27.3 ± 7.72-150 | 24.6 ± 7.12-160 |
| LVPES (mm Hg) | 109 ± 4 | 107 ± 6 | 101 ± 112-150 | 95 ± 102-160 |
| Minimum LVP (mm Hg) | 0.6 ± 0.7 | 0.7 ± 1.3 | 10.5 ± 2.02-150 | 8.6 ± 2.12-160 |
| Mean LAP (mm Hg) | 4.2 ± 2.0 | 3.4 ± 2.7 | 22.0 ± 5.32-150 | 17.7 ± 4.22-160 |
| VED(ml) | 49.4 ± 11.2 | 48.6 ± 11.0 | 59.9 ± 15.32-150 | 57.8 ± 15.22-160 |
| VES (ml) | 32.5 ± 7.5 | 31.8 ± 7.8 | 48.6 ± 12.32-150 | 44.7 ± 11.52-160 |
| Stroke volume (ml) | 16.9 ± 4.4 | 16.7 ± 3.9 | 11.4 ± 4.12-150 | 13.0 ± 4.62-160 |
| Ea (mm Hg/ml) | 6.9 ± 1.9 | 6.8 ± 1.8 | 9.6 ± 2.92-150 | 7.9 ± 2.32-160 |
| TSR (mm Hg ml/min) | 0.063 ± 0.016 | 0.059 ± 0.013 | 0.084 ± 0.0222-150 | 0.065 ± 0.0152-160 |
| τ (ms) | 31.1 ± 3.7 | 30.9 ± 3.7 | 41.9 ± 12.12-150 | 37.7 ± 10.42-160 |
| CBF (ml/min) | 33.6 ± 6.4 | 34.1 ± 7.0 | 42.8 ± 14.02-150 | 49.1 ± 16.02-160 |
| Plasma ET-1 (fmol/ml) | 7.3 ± 1.7 | 18.2 ± 1.92-160 | 14.1 ± 3.02-150 | 26.1 ± 3.42-160 |
LVP, LV pressure; LAP, LA pressure; Ea, arterial elastance; τ, time constant of LV relaxation; and CBF, coronary blood flow. Values are mean ± S.D. (n = 7).
↵2-150 P < .05, control values after CHF versus corresponding control values before CHF.
↵2-160 P < .05, ET-1 blocker versus corresponding control value.