Table 1

Effects of different 5-HT1A agonists on behavior in defensive aggression test

DrugDosenALT OpponentDefenseClinchSocial ExploreNonsocial ExploreGroom
mg/kg
Vehicle03888.8  ± 22.864.2  ± 4.39.7  ± 1.02.5  ± 1.019.4  ± 3.32.5  ± 1.5
Alnespirone1870.9  ± 24.173.9  ± 6.68.8  ± 1.22.3  ± 1.114.3  ± 6.00.35  ± 0.35
5851.9  ± 14.278.4  ± 3.512.8  ± 3.72.3  ± 1.63.9  ± 2.20  ± 0
10869.1  ± 22.679.1  ± 5.113.4  ± 2.91.7  ± 1.45.5  ± 3.30  ± 0
8-OH-DPAT0.1876.3  ± 47.465.0  ± 5.915.6  ± 3.70.7  ± 0.413.5  ± 7.31.2  ± 1.2
0.25657.5  ± 29.169.1  ± 9.710.2  ± 2.90.5  ± 0.216.9  ± 8.72.9  ± 2.8
0.5839.9  ± 11.182.5  ± 1.78.6  ± 1.90.7  ± 0.37.3  ± 1.10.5  ± 0.4
Buspirone0.5763.7  ± 40.673.8  ± 7.912.2  ± 5.31.7  ± 0.99.5  ± 2.80.8  ± 0.6
1.0789.8  ± 51.760.9  ± 8.715.3  ± 3.51.8  ± 1.218.6  ± 8.40.1  ± 0.1
Ipsapirone0.5894.1  ± 27.663.7  ± 6.69.1  ± 1.92.5  ± 1.122.8  ± 6.01.1  ± 0.9
1.0878.4  ± 29.672.4  ± 5.312.3  ± 2.20.5  ± 0.414.3  ± 5.30.5  ± 0.3
Eltoprazine0.5893.5  ± 31.165.3  ± 10.76.5  ± 2.12.3  ± 1.125.9  ± 11.10  ± 0
1.0896.4  ± 40.164.2  ± 12.87.4  ± 1.91.1  ± 0.927.3  ± 13.20  ± 0
  • Data are mean ± S.E.M. ALT, attack latency time (s). Behaviors are expressed as percent of observation time (10 min). ANOVA revealed no significant differences between treatments.