Tissue | CLup,app (ml/min/g Tissue) | ||
---|---|---|---|
Oxy | Glc-O-C8-Oxy | Man-O-C8-Oxy | |
Heart | 0.026 ± 0.001 | 0.038 ± 0.001 | 0.032 ± 0.002 |
Lung | 0.046 ± 0.001 | 0.061 ± 0.001 | 0.053 ± 0.003 |
Spleen | 0.030 ± 0.002 | 0.036 ± 0.002 | 0.032 ± 0.001 |
Kidney | 0.387 ± 0.062 | 1.053 ± 0.053 | 3.594 ± 0.171 |
Muscle | 0.019 ± 0.002 | 0.026 ± 0.000 | 0.024 ± 0.001 |
Brain | 0.004 ± 0.001 | 0.006 ± 0.000 | 0.005 ± 0.001 |
BM | 0.032 ± 0.002 | 0.039 ± 0.001 | 0.053 ± 0.022 |
SI | 0.069 ± 0.006 | 0.509 ± 0.044 | 0.938 ± 0.075 |
Liver | 0.052 ± 0.005 | 0.083 ± 0.004 | 0.139 ± 0.019 |
Apparent tissue uptake clearance (CLup,app) of sugar-introduced oxytocin derivatives by various rat tissues. 3H-labeled derivatives were administrated at a dose of 1 nmol/kg. CLup,app was calculated by the total radio activity. BM and SI represent bone marrow and small intestine, respectively. Values represent means ± S.E. of three rats.