Table 1

Tissue uptake clearance of the glycosylated derivatives of AVP

Tissue	CLup,app (ml/min/g Tissue)
Tissue	AVP	Glc-O-C8-AVP	Gal-O-C8-AVP	Man-O-C8-AVP	Man(α)-O-C8-AVP	2dGlc-O-C8-AVP
Heart	0.048 ± 0.003	0.032 ± 0.002	0.032 ± 0.001	0.032 ± 0.002	0.041 ± 0.002	0.036 ± 0.001
Lung	0.101 ± 0.011	0.084 ± 0.034	0.060 ± 0.002	0.047 ± 0.001	0.063 ± 0.003	0.061 ± 0.003
Spleen	0.108 ± 0.003	0.030 ± 0.002	0.035 ± 0.001	0.034 ± 0.001	0.039 ± 0.001	0.038 ± 0.001
Kidney	0.488 ± 0.040	2.430 ± 0.154	0.361 ± 0.039	3.428 ± 0.235	0.669 ± 0.012	3.601 ± 0.134
Muscle	0.030 ± 0.001	0.017 ± 0.006	0.020 ± 0.001	0.026 ± 0.003	0.025 ± 0.002	0.019 ± 0.001
Brain	0.014 ± 0.001	0.007 ± 0.001	0.007 ± 0.001	0.007 ± 0.000	0.008 ± 0.001	0.008 ± 0.000
BM	0.097 ± 0.007	0.060 ± 0.002	0.054 ± 0.003	0.060 ± 0.004	0.047 ± 0.001	0.058 ± 0.003
SI	0.102 ± 0.015	0.039 ± 0.003	0.039 ± 0.002	0.063 ± 0.002	0.083 ± 0.002	0.077 ± 0.003
Liver	0.125 ± 0.008	0.026 ± 0.003	0.031 ± 0.001	0.030 ± 0.004	0.037 ± 0.002	0.048 ± 0.002

Apparent tissue uptake clearance (CLup,app) of sugar-introduced AVP derivatives by various rat tissues. ³H-labeled AVP and derivatives were administrated at a dose of 1 nmol/kg. CLup,app was calculated by the total radio activity. BM and SI represent bone marrow and small intestine, respectively. Values represent means ± S.E. of three rats.