ANOVA table and ED50 values for the effects of amphetamine evaluated in water- and caffeine-drinking rats
| Groups | % Generalization | ED50 | Response Rate | ED50 |
|---|---|---|---|---|
| Amphetamine (training dose: 0.4 mg/kg nicotine) | ||||
| Water-dr (W)6-a | F 3,15 = 6.458;p = .005 | 0.51 (0.33–0.79) | F 5,25 = 11.98;p < .001 | 0.82 (0.61–0.92) |
| Water-dr now Caff-dr (W→C) | F 4,16 = 1.062; p = .407 | n.c. | F 5,20 = 12.86;p < .001 | 1.63 (1.18–2.25) |
| Caff-dr (C)6-a | F 4,16 = 0.994; p = .423 | n.c. | F 5,25 = 9.792; p < .001 | 1.00 (0.61–1.45) |
| Caff-dr now Water-dr (C→W) | F 4,16 = 0.995; p = .439 | n.c. | F 5,20 = 7.557; p < .001 | 1.37 (1.04–1.88) |
| W versus C6-a | F 1,20 = 6.010; p = .034 | F 1,40 = 0.261; p = .621 | ||
| W→C versus C→W | F 1,20 = 0.448;p = .522 | F 1,32 = 0.091;p = .770 | ||
| W versus W→C | F 1,8 = 12.96; p = .023 | F 1,16 = 22.33;p = .009 | ||
| C versus C→W | F 1,8 = 1.006; p = .373 | F 1,16 = 4.457;p = .102 | ||
Shown are the F values, degrees of freedom, and significance levels of difference (p values) revealed by ANOVA of the dose-response functions (percentage of generalization to 0.4 mg/kg of nicotine and changes in rates of responding) for amphetamine. W and C represent water- and caffeine-drinking rats, respectively. W→C represents water-drinking rats that had tap water replaced with caffeine solution in this study. C→W represents caffeine-drinking rats that had caffeine solution replaced with tap water. See caption of Fig. 9 and Results for more details on this study. One-way repeated measures ANOVA was used to ascertain a statistically significant effect of drug treatment versus vehicle treatment (four upper rows). Two-way repeated measures ANOVA on one repeated factor was used to compare dose-response effects between groups (fifth and sixth rows). Two-way repeated measures ANOVA on two repeated factors was used to compare dose-response effects within the same group (before versus after; seventh and eighth rows). Where appropriate, ED50 values (with 95% CL) were calculated from the dose-response functions (Fig. 9). See footnote to Table 1 for additional details.
↵6-a Data from Table 3.