ANOVA table for the effects of caffeine, amphetamine, cocaine, GBR-12909, and CGS 10746B in water- and caffeine-drinking rats trained to discriminate either 0.4 mg/kg of nicotine from saline or 0.1 mg/kg of nicotine from saline
| Drug | % Generalization | Response rate | ||||
|---|---|---|---|---|---|---|
| Water-dr | Caff-dr | Water-dr versus Caff-dr | Water-dr | Caff-dr | Water-dr versus Caff-dr | |
| Training dose: 0.4 mg/kg nicotine | ||||||
| Caffeine | F 5,25 = 1.924 | F 5,25 = 0.999 | F 1,40 = 3.032 | F 5,25 = 12.67 | F 5,25 = 26.05 | F 1,40 = 0.106 |
| p = .126 | p = .438 | p = .112 | p< .001 | p < .001 | p = .752 | |
| Amphetamine | F 3,15 = 6.458 | F 4,16 = 0.994 | F 1,20 = 6.010 | F 5,25 = 11.98 | F 5,25 = 9.792 | F 1,40 = 0.261 |
| p = .005 | p = .423 | p = .034 | p< .001 | p < .001 | p = .621 | |
| Cocaine | F 5,25 = 2.824 | F 5,20 = 0.977 | F 1,36 = 1.017 | F 5,25 = 3.869 | F 5,20 = 2.898 | F 1,36 = 0.623 |
| p = .037 | p = .455 | p = .340 | p = .010 | p = .040 | p = .450 | |
| GBR-12909 | F 4,18 = 4.113 | F 4,15 = 1.318 | F 1,24 = 13.55 | F 5,25 = 11.19 | F 5,20 = 4.737 | F 1,36 = 0.166 |
| p = .014 | p = .308 | p = .005 | p< .001 | p = .005 | p = .693 | |
| CGS 10746B | F 3,12 = 4.656 | F 3,12 = 1.001 | F 1,16 = 5.801 | F 4,16 = 21.12 | F 4,16 = 28.99 | F 1,24 = 3.427 |
| p = .022 | p = .426 | p = .043 | p< .001 | p < .001 | p = .101 | |
| Training dose: 0.1 mg/kg nicotine | ||||||
| Amphetamine | F 4,20 = 3.657 | F 4,20 = 1.566 | F 1,29 = 10.12 | F 4,20 = 8.591 | F 4,20 = 20.26 | F 1,30 = 1.255 |
| p = .022 | p = .222 | p = .010 | p< .001 | p < .001 | p = .289 | |
| Cocaine | F 5,25 = 4.637 | F 5,25 = 1.073 | F 1,30 = 11.03 | F 5,25 = 5.181 | F 4,20 = 3.213 | F 1,30 = 0.002 |
| p = .004 | p = .396 | p = .008 | p = .002 | p = .034 | p = .964 | |
| GBR-12909 | F 3,15 = 8.580 | F 3,15 = 1.014 | F 1,20 = 6.698 | F 3,15 = 7.056 | F 3,15 = 7.265 | F 1,20 = 0.003 |
| p = .001 | p = .414 | p = .027 | p = .004 | p = .003 | p = .958 | |
Shown are the F values, degrees of freedom, and significance levels of difference (p values) revealed by ANOVA of the dose-response functions (percentage of generalization to the training dose of nicotine and changes in rates of responding) for each treatment as listed in the first column. See Figs. 2 to 5 for dose-response functions of the drugs and the footnote to Table 1 for other details.