Effect of 5-HT4 receptor agonists on heart rate
| Drug | Time | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 3 | 5 | 10 | 15 | 20 | 30 | 40 | 50 | 60 | |
| nmol/kg i.v. | min | |||||||||
| ML 10302 | ||||||||||
| 100 (n = 5) | 73 ± 10 | 94 ± 7 | 90 ± 9 | 78 ± 8 | 89 ± 8 | 76 ± 5 | 86 ± 9 | 80 ± 9 | 72 ± 5 | 82 ± 14 |
| 300 (n = 4) | 98 ± 15 | 99 ± 8 | 93 ± 7 | 94 ± 5 | 86 ± 3 | 88 ± 3 | 83 ± 7 | 87 ± 8 | 90 ± 6 | 98 ± 5 |
| SR 59768 | ||||||||||
| 100 (n = 5) | 88 ± 7 | 98 ± 7 | 97 ± 9 | 86 ± 7 | 89 ± 8 | 88 ± 7 | 86 ± 4 | 86 ± 7 | 90 ± 8 | 86 ± 7 |
| 300 (n = 4) | 95 ± 11 | 88 ± 4 | 92 ± 7 | 89 ± 9 | 85 ± 10 | 77 ± 6 | 84 ± 9 | 91 ± 11 | 90 ± 10 | 85 ± 13 |
| Cisapride | ||||||||||
| 1000 (n = 5) | 94 ± 10 | 104 ± 9 | 101 ± 8 | 100 ± 13 | 92 ± 11 | 95 ± 11 | 94 ± 14 | 95 ± 12 | 93 ± 13 | 97 ± 11 |
| 3000 (n = 4) | 91 ± 6 | 122 ± 10** | 113 ± 10* | 103 ± 13 | 94 ± 8 | 95 ± 7 | 91 ± 10 | 92 ± 10 | 88 ± 8 | 89 ± 9 |
Values are means ± S.E. beats/min; * p < .05; ** p < .01. Because of the short duration of the observed effect, this table reflects data only for the first 60 min after drug administration.