Dose | SBP | HR | |
---|---|---|---|
mg/kg/day | mm Hg | beats/min | |
Control-1 | 132.5 ± 2.5 | 343.1 ± 14.7 | |
KRH-594 | 3 | 110.2 ± 3.32-150 | 328.4 ± 12.7 |
KRH-594 | 10 | 90.0 ± 2.62-150 | 341.2 ± 16.1 |
KRH-594 | 30 | 84.4 ± 2.62-150 | 343.5 ± 7.9 |
TCV-116 | 1 | 100.7 ± 3.82-150 | 384.8 ± 9.3 |
TCV-116 | 3 | 93.1 ± 3.02-150 | 346.4 ± 5.5 |
Control-2 | 134.4 ± 2.6 | 331.5 ± 16.2 | |
Hydralazine | 10 | 91.9 ± 2.22-160 | 499.4 ± 13.62-160 |
SBP and HR were measured on day 13 after balloon injury as described in Materials and Methods. Control-2 is for hydralazine treatment, which was performed separately from KRH and TCV treatments. Data are expressed as mean ± S.E. for 8 to 10 rats.
↵2-150 p < .01 versus control-1 by Dunnett’s multiple comparison test.
↵2-160 p < .01 versus control-2 by Student’st test.