Drug | mg/kg | % net AUC (mean ± S.E.M.) | ||
---|---|---|---|---|
mPFC | NAC | log[mPFC]−log[NAC] | ||
VEH | 0 | 9 ± 37 (6) | −13 ± 14 (6) | |
APZ | 2 | 351 ± 82** (6) | 16 ± 23 (9) | 1.35 |
10 | 1310 ± 287*** (5) | 135 ± 21*** (5) | 0.99 | |
CLOZ | 5 | 321 ± 70** (6) | 78 ± 34* (7) | 0.62 |
20 | 556 ± 142** (7) | 133 ± 38* (6) | 0.63 | |
OLAN | 1 | 202 ± 66* (7) | 181 ± 70** (6) | 0.05 |
10 | 560 ± 82*** (6) | 280 ± 39** (6) | 0.30 | |
RISP | 0.1 | 208 ± 26* (4) | 265 ± 76*** (4) | −0.10 |
1 | 358 ± 79*** (4) | 454 ± 33*** (4) | −0.11 | |
SUL | 10 | 153 ± 36* (6) | 384 ± 49*** (8) | −0.40 |
25 | 266 ± 101** (4) | 286 ± 60** (4) | −0.03 | |
HAL | 0.1 | 88 ± 29 (4) | 300 ± 100** (5) | −0.54 |
1 | 137 ± 45* (6) | 371 ± 52*** (7) | −0.43 |
The values of log[mPFC]−log[NAC] are the differences in the logarithm of % net AUC between the mPFC and the NAC. Numbers of rats in each treatment group are in parentheses. * p < .05, ** p < .01, *** p < .001 by one-way ANOVA compared to the vehicle control.