Effect of MCAO and drug treatment on blood pressure
| Treatment | MABP | ||
|---|---|---|---|
| Baseline | 45 min after MCAO | 15 min after reperfusion | |
| mm Hg | |||
| Vehicle, n = 4 | 144 ± 6 | 149 ± 10 | 142 ± 8 |
| FK506, n = 4 | 143 ± 6 | 160 ± 8 | 148 ± 4 |
| ASM-981,n = 4 | 139 ± 8 | 159 ± 3 | 147 ± 11 |
The MABP was assessed in awake freely moving rats, over a period of 5 min, before surgery (baseline), 45 min after MCAO (15 min after drug application), and 15 min after reperfusion. Animals were treated with vehicle, 5 mg/kg FK506, or 5 mg/kg ASM-981. Results are the mean ofn values ± S.E.M.