PK parameters for MPL disposition (dose = 50 mg/kg) in rats
| Parameters (U) | Value |
|---|---|
| Biexponential fitting | |
| C 1 (μg/ml) | 56.3 |
| C 2 (μg/ml) | 14.5 |
| λ1(h−1) | 9.88 |
| λ2 (h−1) | 1.22 |
| Area/moment analysis | |
| AUC (μg · h/ml) | 17.6 |
| AUMC (μg · h−2/ml) | 10.3 |
| MRT (min) | 35.2 |
| PK analysis | |
| T ½(min) | 34.1 |
| CL (l/h/kg) | 2.85 |
| V C(l/kg) | 0.71 |
| V ss (l/kg) | 1.67 |
AUC, area under the curve; AUMC, area under the first-moment curve; MRT, mean residence time.