Table 1

Renal handling of tracer concentrations of [14C]benzoate and [3H]hippurate by the constant flow (8 ml/min) single-pass IPK1-a

Rat WeightWeight of left kidneyWeight of right kidney% ReabsorptionFlow Rate[14C]Benzoate and [14C]Hippurate[3H]Hippurate
Na+GlucoseGFRUrineCLtot,KCLu,KCLmet,KEKFE(BA)EK{mi}CLtot,K{pmi}EK{pmi}FE(HA)
g ml/min/g ml/min/g ml/min/g
Observed402 ± 111.54 ± 0.101.85 ± 0.0873 ± 1195 ± 40.34 ± 0.090.11 ± 0.051.13 ± 0.170.011 ± 0.011.12 ± 0.170.26 ± 0.040.27 ± 0.190.39 ± 0.091.05 ± 0.210.241-150 ± 0.057.7 ± 1.0
Predicted1-b 1.150.01121.140.260.270.391.070.247.7

  • ↵1-150  Different from EK{mi},p < .02.

  • ↵1-a n = 5, mean ± S.D.; the concentration of [3H]hippurate was 44,000 ± 5,400 dpm/ml (0.35 ± 0.04 μM), whereas the concentration of [14C]benzoate was 30,200 ± 4,100 dpm/ml (0.86 ± 0.12 μM); the average plasma flow rate was 4.447 ± 0.29 ml/min/g.

  • ↵1-b Based on the parameters outlined in Table 3 and equations shown in Table 2.