Drugs | Catalepsy |
---|---|
All-or-none scoring (no. of cataleptic mice) | |
Haloperidol (0.25) | 6 /10 |
(R)α-MeHA (20) | 0 /10 |
Haloperidol + (R)α-MeHA | 5 /10 |
Haloperidol (0.25) | 14 /22 |
Ciproxifan (3) | 2 /18 |
Haloperidol + ciproxifan | 15 /22 |
Duration of catalepsy (in sec, n = 20–40) | |
Haloperidol (0.8) | 121 ± 10 |
Haloperidol (0.8) + (R)α-MeHA (20) | 143 ± 14 |
Haloperidol (0.8) + ciproxifan (3) | 128 ± 16 |
Drugs were administered intraperitoneally at the indicated dosage (mg/kg). H3-receptor ligands were administered 2 h and haloperidol 1 h before assessment of catalepsy.