Effects of clozapine and olanzapine on t-MeHA levels in various mouse brain regions
| ED50 (mg/kg) | Maximal Effect (% of Control) | |||
|---|---|---|---|---|
| Clozapine | Olanzapine | Clozapine | Olanzapine | |
| Hypothalamus | 1.5 ± 0.6 | 3.5 ± 1.6 | 148 ± 4 | 157 ± 3 |
| Striatum | 0.9 ± 0.2 | 3.0 ± 0.6 | 182 ± 3 | 210 ± 4 |
| Cerebral cortex | 1.6 ± 0.8 | 2.9 ± 0.9 | 182 ± 6 | 191 ± 8 |