Table 1

Plasma and brain tissue concentrations of fluoxetine and norfluoxetine

No. of Days after Last Fluoxetine Injection	Plasma^1-a		Brain tissue^1-b
No. of Days after Last Fluoxetine Injection	FLU	NOR	FLU	NOR
	nM		pmol/mg
Vehicle	nd	nd	nd	nd
2	nd	439.53 ± 99.68	0.13 ± 0.06^1-c	41.42 ± 9.43
4	nd	3.71 ± 2.49^1-d	nd	0.36 ± 0.08
7	nd	nd	nd	0.09 ± 0.05^1-e
14	nd	nd	nd	nd
28	nd	nd	nd	nd
60	nd	nd	nd	nd

FLU, fluoxetine; NOR, norfluoxetine; nd, not detectable. Data represent mean ± S.E.M. of seven to eight rats per group.
↵1-a Detection limit in plasma was 10 nM for fluoxetine, 6 nM for norfluoxetine.
↵1-b Detection limit in brain tissue was 0.15 pmol/mg wet weight tissue for fluoxetine, 0.20 pmol/mg for norfluoxetine.
↵1-c Mean represents two of seven rats with levels near the detection limit (mean = 13.0 ± 3.0 nM) and the remaining five rats with undetectable levels.
↵1-d Mean represents four of seven rats with levels near the detection limit (mean = 0.23 ± 0.06 pmol/mg) and the remaining three rats with undetectable levels.
↵1-e Mean represents three of eight rats with levels near the detection limit (mean = 0.24 ± 0.03 pmol/mg) and the remaining five rats with undetectable levels.