Table 1

Effect of PD 81,723 (3 μM) on equilibrium binding characteristics of agonist ([¹²⁵I]ABA) and antagonist ([³H]DPCPX) in CHO-A₁ cell and rat brain membranes

	[³H]DPCPX		[¹²⁵I]ABA
	K_d		B_max		K_d		B_max
	Control	PD 81,723	Control	PD 81,723	Control	PD 81,723	Control	PD 81,723
	nM		fmol/mg		nM		fmol/mg
CHO-A₁cells	0.23	0.32	2847 ± 302	2609 ± 311	0.38	0.45	380 ± 73	475 ± 116
	(0.19–0.27)	(0.27–0.35)			(0.16–0.60)	(0.26–0.64)
Rat brain	0.41	0.60	535 ± 65	463 ± 52	1.28	1.06	126 ± 17	130 ± 8
	(0.31–0.49)	(0.42–0.74)			(0.88–1.56)	(0.72–1.30)

Estimates are expressed as the geometric mean with 95% CI (K_d) or mean ± S.E.M. (B_max), n = 5–6.