Effects of PAMP (50 ng/kg/min) on exogenous NE-induced systemic and renal hemodynamics, and urine formation in anesthetized dogs
| MAP (mmHg) | HR (beats/min) | RBF (ml/g/min) | RVR (mmHg/ml/g/min) | GFR (ml/g/min) | FF (%) | UF (μl/g/min) | UNaV (μEq/g/min) | FENa (%) | |
|---|---|---|---|---|---|---|---|---|---|
| Saline infusion | |||||||||
| Control | 130.8 ± 7.7 | 156.2 ± 14.3 | 4.0 ± 0.6 | 36.0 ± 6.5 | 0.80 ± 0.04 | 38.3 ± 7.0 | 21.0 ± 4.4 | 3.72 ± 0.70 | 3.18 ± 0.72 |
| NE | 133.0 ± 9.6 | 148.8 ± 14.33-a | 3.4 ± 0.63-a | 43.6 ± 8.33-a | 0.64 ± 0.043-a | 33.7 ± 4.4 | 13.8 ± 2.83-a | 2.15 ± 0.363-a | 2.27 ± 0.39 |
| % change | 1.4 ± 1.9 | −4.9 ± 1.5 | −14.3 ± 3.9 | 19.5 ± 7.1 | −20.0 ± 6.0 | −9.0 ± 6.1 | −33.8 ± 4.8 | −41.4 ± 1.5 | −24.2 ± 6.5 |
| PAMP infusion | |||||||||
| Control | 128.0 ± 8.5 | 157.2 ± 13.3 | 4.1 ± 0.7 | 35.3 ± 6.8 | 0.78 ± 0.06 | 30.0 ± 4.5 | 23.8 ± 5.8 | 4.26 ± 0.72 | 3.65 ± 0.58 |
| NE | 130.8 ± 8.3 | 151.1 ± 12.7b | 3.6 ± 0.73-a | 39.6 ± 8.8 | 0.60 ± 0.083-a | 29.0 ± 3.9 | 15.8 ± 3.13-a | 2.56 ± 0.48b | 2.87 ± 0.37 |
| % change | 2.2 ± 0.9 | −3.9 ± 0.5 | −13.7 ± 3.9 | 19.7 ± 6.5 | −24.2 ± 7.0 | −9.6 ± 9.6 | −31.0 ± 5.4 | −40.0 ± 3.3 | −16.3 ± 13.2 |
Each value represents the mean ± S.E.M. of five dogs.
↵3-a P < .05, b P < .01 versus each control value (Student’s t test).