Compound | RIa | IC50 (μM) | Activity |
---|---|---|---|
Reference compounds | |||
Aminoguanidine | 1.0 | 0.11 | Active |
N-methyl hydroxylamine | 2100.1 | 221.56 | Inactive |
Aliphatic hydroxylamines | |||
O-1-allyl, 1 | 2.2 | 0.23 | Active |
O-1-pentyl, 2 | 3.3 | 0.35 | Active |
O-2-butyl, 3 | 6.6 | 0.70 | Active |
O-1-hexyl, 4 | 11.1 | 1.17 | Active |
O-1-pent-4-ynyl, 5 | 23.3 | 2.46 | Active |
O-1-(2-methyl)propyl, 6 | 35.6 | 3.76 | Active |
O-1-octyl, 7 | 64.6 | 6.82 | Marginal |
O-1-decyl, 8 | 115.6 | 12.20 | Negative |
O-1-(3-methyl)butyl, 9 | 147.5 | 15.56 | Marginal |
Benzylic hydroxylamines | |||
O-1-E-Cinnamyl, 10 | 10.8 | 1.14 | Marginal |
O-p-hydroxybenzyl, 11 | 12.6 | 1.33 | Active |
O-p-hydroxy-m-bromobenzyl, 12 | 14.8 | 1.56 | Marginal |
O-m-methoxybenzyl, 13 | 20.6 | 2.17 | Marginal |
O-p-methoxybenzyl, 14 | 36.2 | 3.82 | Marginal |
O-p-bromobenzyl, 15 | 52.6 | 5.55 | Marginal |
O-benzyl, 16 | 161.7 | 17.06 | Negative |
a Relative Inhibition (RI) ratios were obtained by dividing the IC50 value for each compound by the IC50 value for the reference compound aminoguanidine (0.11 μM).