Comparison of degree of reduction of hormone responses to 8-OH-DPAT with reductions in the levels of G proteins in the hypothalamus in rats treated with various doses of fluoxetine
| Fluoxetine Dose (mg/kg/day, ip) | Responses to 8-OH-DPAT (% of Control)2-a | % of Control Group | ||||
|---|---|---|---|---|---|---|
| Oxytocin | ACTH | Corticosterone | Gz | Gi1 | Gi3 | |
| 0 (Saline) | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 99.8 |
| 5 | 50.6 | 62.5 | 67.3 | 93.9 | 96.4 | 126.5 |
| 7.5 | 33.1 | 41.1 | 28.3 | 69.4 | 110.1 | 122.2 |
| 10 | 0.6 | 1.7 | 28.0 | 73.5 | 62.6 | 96.5 |
↵2-a The hormone responses to 8-OH-DPAT (minus baseline levels) in rats treated with no fluoxetine (i.e., saline) were set as 100% and are for oxytocin, 35.6 pg/ml; for ACTH, 281.4 pg/ml; and for corticosterone, 15.9 μg/dl.